Overproduction of clavulanic acid by UV mutagenesis of Streptomyces clavuligerus

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Overproduction of Clavulanic Acid by UV Mutagenesis of Streptomyces clavuligerus

Clavulanic acid is produced industrially by fermentation of Streptomyces clavuligerus and researches have increased its production by strain improvement, recombinant DNA technology, and media composition and growth condition optimization. The main objective of this study was to increase the level of clavulanic acid production from Streptomyces clavuligerus (DSM 738), using UV irradiation. After...

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Overproduction of Clavulanic Acid by UV Mutagenesis of Streptomyces clavuligerus

Clavulanic acid is produced industrially by fermentation of Streptomyces clavuligerus and researches have increased its production by strain improvement, recombinant DNA technology, and media composition and growth condition optimization. The main objective of this study was to increase the level of clavulanic acid production from Streptomyces clavuligerus (DSM 738), using UV irradiation. After...

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overproduction of clavulanic acid by uv mutagenesis of streptomyces clavuligerus

clavulanic acid is produced industrially by fermentation of streptomyces clavuligerus and researches have increased its production by strain improvement, recombinant dna technology, and media composition and growth condition optimization. the main objective of this study was to increase the level of clavulanic acid production from streptomyces clavuligerus (dsm 738), using uv irradiation. after...

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Enhancement of clavulanic acid production by mutant Streptomyces clavuligerus

β-lactam antibiotics are among the most popular classes of antibacterial agents, whose mechanism of action consists on the inhibition of bacterial cell wall synthesis.1 The production of β-lactamase is the most important mechanism for bacterial resistance to β-lactam antibiotics.2 Secondary metabolites produced by bacteria exhibit potent biological activities and have been developed extensively...

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ژورنال

عنوان ژورنال: Journal of Biotechnology

سال: 2007

ISSN: 0168-1656

DOI: 10.1016/j.jbiotec.2007.07.931